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Studies & Research Studies & Research

Research, publications and featured articles about deoxidized hydrogen rich water
Antioxidant
  1. Hydrogen-rich water for green reduction of graphene oxide suspensions.
  2. Cathodic amelioration of the adverse effects of oxidative stress accompanying procedures necessary for cryopreservation of embryonic axes of recalcitrant-seeded species.
  3. Antioxidant effects of reduced water produced by electrolysis of sodium chloride solutions.
  4. The mechanism of the enhanced antioxidant effects against superoxide anion radicals of reduced water produced by electrolysis.
  5. In Vitro Physicochemical Properties of Neutral Aqueous Solution Systems (Water Products as Drinks) Containing Hydrogen Gas, 2-Carboxyethyl Germanium Sesquioxide, and Platinum Nanocolloid as Additives.
  6. Antioxidant activities of nano-bubble hydrogen-dissolved water assessed by ESR and 2, 2?-bipyridyl methods.
  7. Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein.
  8. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
  9. Molecular hydrogen as a novel antioxidant: overview of the advantages of hydrogen for medical applications.
  10. Protective effect of electrolyzed reduced water on the paraquat-induced oxidative damage of human lymphocyte DNA.
  11. Electrolyzed-reduced water confers increased resistance to environmental stresses.
  12. Electrolyzed-reduced water increases resistance to oxidative stress, fertility, and lifespan via insulin/IGF-1-like signal in C. elegans.
  13. ONOOH does not react with H2.
  14. Administration of hydrogen-rich saline protects mice from lethal acute graft-versus-host disease (aGVHD).
  15. Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.
  16. Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage.
  17. Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water–participation of Pt nanoparticles.
  18. Electrolyzed reduced water prolongs caenorhabditis elegans lifespan, in Animal Cell Technology: Basic & Applied Aspects.
  19. Extension of the Lifespan of Caenorhabditis elegans by the Use of Electrolyzed Reduced Water.
  20. Electrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect: a feeding test with rats.
Bones
  1. Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast.
  2. Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle.
  3. Hydrogen water consumption prevents osteopenia in ovariectomized rats.
  4. Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide.
  5. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages.
  6. Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials.
  7. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.
  8. Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats.
  9. Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells.
  10. Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats.
  11. Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study.
  12. Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema
  13. Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation.
Brain
  1. Inhalation of Hydrogen Gas Protects Cerebrovascular Reactivity Against Moderate but Not Severe Perinatal Hypoxic Injury in Newborn Piglets.
  2. Hydrogen-rich saline attenuates neuronal ischemia-reperfusion injury by protecting mitochondrial function in rats.
  3. Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury.
  4. Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs.
  5. Hydrogen is neuroprotective against surgically induced brain injury.
  6. Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats.
  7. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease.
  8. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.
  9. Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice.
  10. Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins.
  11. Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats.
  12. Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway.
  13. Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury.
  14. The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest.
  15. Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus.
  16. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats.
  17. Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress.
  18. Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress.
  19. Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water.
  20. Electrochemically reduced water protects neural cells from oxidative damage.
  21. Effects of Hydrogen Gas in a Mouse Cold Induced Brain Injury Model.
  22. Neuroprotective effects of hydrogen gas on brain in three types of stress models: alpha P-31-NMR study.
  23. Neuroprotective effects of hydrogen gas on brain in three types of stress models: A P-31-NMR and ESR study.
  24. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress.
  25. Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats.
  26. Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis.
  27. Protective effects of hydrogen on fetal brain injury during maternal hypoxia.
  28. Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage.
  29. Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice.
  30. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.
  31. Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice.
  32. Hydrogen protects rats from dermatitis caused by local radiation.
  33. Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice.
  34. Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs.
  35. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study.
  36. Targeting molecular hydrogen to mitochondria: Barriers and gateways.
  37. Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H2 Antioxidant Species Inside Mitochondria
  38. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.
  39. Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest.
  40. Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning.
  41. Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice.
  42. Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity.
  43. Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats.
  44. Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride.
  45. Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer’s disease.
  46. Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats.
  47. Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning.
  48. Molecular Hydrogen and its Potential Application in Therapy of Brain Disorders.
  49. The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles.
  50. Hydrogen supplementation of preservation solution improves viability of osteochondral grafts.
  51. Neuroprotective effects of hydrogen gas on brain in three types of stress models: a P-31 NMR and ESR study.
  52. Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats.
  53. Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats.
  54. Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture.
  55. Nuclear factor-kappaB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits.
  56. Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits.
Cancer
  1. Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells
  2. Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like c
  3. On the antitumor properties of biomedical magnesium metal.
  4. Hyperbaric hydrogen therapy: a possible treatment for cancer.
  5. Suppression of invasion of cancer cells and angiogenesis by electrolyzed reduced water.
  6. Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells.
  7. Electrolyzed reduced water induces differentiation in K-562 human leukemia cells
  8. Anticancer Effect of Alkaline Reduced Water.
  9. Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imagin
  10. Mechanism of Cancer Cell Death Induced by Hydrogen Discharged from Palladium Base Hydrogen Storage Alloy
  11. Influence of Active Hydrogen Discharged from Palladium-Nickel Alloy Powder on Biological Cells.
  12. growth suppression of HL60 and L6 cells by atomic hydrogen,
  13. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.
  14. Magnesium metal-A potential biomaterial with antibone cancer properties.
  15. Suppression of two-stage cell transformation by electrolyzed reduced water containing platinum nanoparticles,
  16. Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation.
  17. Suppression of two-stage cell transformation by electrolyzed reduced water/platinum nanocolloids.
  18. Response of five established solid transplantable mouse tumors and one mouse leukemia to hyperbaric hydrogen
  19. Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer
  20. Electrolyzed Reduced Water Which Can Scavenge Active Oxygen Species Suppresses Cell Growth and Regulates Gene Expression of Animal Cells.
  21. Neutral pH Hydrogen-Enriched Electrolyzed Water Achieves Tumor-Preferential Clonal Growth Inhibition Over Normal Cells and Tumor Invasion Inhibition Concurrently With Intracellular Oxidant
  22. Platinum nanocolloid-supplemented hydrogen dissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells.
  23. Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione.
  24. Inhibitory effect of electrolyzed reduced water on tumor angiogenesis.
Eye and Ear
  1. Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs through an Antioxidant Effect.
  2. Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats.
  3. Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression.
  4. Suppression of glutamate-induced neural cell death by electrolyzed-reduced water, in Animal Cell Technology: Basic & Applied Aspects.
  5. Hydrogen protects auditory hair cells from free radicals.
  6. Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species.
  7. Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs.
  8. Capabilities of hydrogen Molecules for use in the prevention and treatment in noise induced hearing loss.
  9. Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia-Reperfusion Injury.
  10. Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils.
  11. Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress.
  12. Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush.
  13. Hydrogen protects vestibular hair cells from free radicals.
  14. Hydrogen-rich saline ameliorates the retina against light-induced damage in rats.
  15. Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model.
  16. Hydrogen saline prevents selenite-induced cataract in rats.
  17. Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina.
  18. Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs.
H2 Bacteria
  1. Recently published papers: More about EGDT, experimental therapies and some inconvenient truths.
  2. The potential benefits of hydrogen-rich saline in ischemia and reperfusion injury.
  3. Future Directions in Hydrogen Studies
  4. Hydrogen therapy may be a promising, safe and effective treatment for diabetic erectile dysfunction: a hypothesis.
  5. Molecular hydrogen and radiation protection.
  6. A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution.
  7. Neuroprotective gases–fantasy or reality for clinical use?
  8. The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance.
  9. Hydrogen: another gas with therapeutic potential.
  10. Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism.
  11. Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production.
  12. Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia.
  13. The use of redox potential in water treatment processes.
  14. MOLECULAR HYDROGEN THERAPY: A MAJOR MILESTONE IN MEDICINE.
  15. Hydrogen therapy: a future option in critical care?
  16. Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW).
  17. Hydrogen as a selective antioxidant: a review of clinical and experimental studies.
  18. Recent advances in hydrogen research as a therapeutic medical gas.
  19. Hydrogen-an endogenous antioxidant in the body.
  20. What Is Functional Water?
  21. Can hydrogen retard the progression of osteoarthritis?
  22. Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.
  23. Hydrogen from a biologically inert gas to a unique antioxidant.
  24. Hydrogen Saline a Real Gas
  25. Therapeutic Antioxidant Medical Gas
  26. Stimulation of human damaged sperm motility with hydrogen molecule.
  27. Dietary fibre and health: the role of hydrogen production.
  28. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases
  29. [Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept].
  30. Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.
  31. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.
  32. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
  33. The 2011 Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research
  34. Water desirable for the human body in terms of oxidation-reduction potential (ORP) to pH relationship.
  35. Molecular hydrogen: An inert gas turns clinically effective.
  36. Serum alkalinization and hydrogen-rich water in healthy men.
  37. Methods of Hydrogen Application
  38. The potential cardioprotective effects of hydrogen in irradiated mice.
  39. Hydrogen as a New Class of Radioprotective Agent.
  40. The Hypothesis of an Effective Safe and Novel Radioprotective Agent Hydrogen-rich Solution.
  41. Therapeutic Effects of Hydrogen on Different Diseases.
  42. Hydrogen: A promising novel treatment for hepatic encephalopathy?
  43. Does alkaline-reduced hexagonal water delay the aging process in Drosophila?
  44. A hypothesis on biological protection from space radiation through the use of new therapeutic gases as medical counter measures.
  45. Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.
  46. A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.
  47. Hydrogen gas: a novel antioxidant for chronic obstructive pulmonary disease.
  48. A hypothesis on chemical mechanism of the effect of hydrogen.
  49. Advanced research on the health benefit of reduced water.
  50. Reduced water for prevention of diseases.
  51. Hydrogen-supplemented drinking water, just soda or an elixir of life?
  52. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents.
  53. Gasotransmitters: growing pains and joys.
  54. The hydrogen highway to reperfusion therapy.
  55. Simulation study on the outlet flow dynamics of a hydride-based hydrogen storage canister for medical use.
  56. Progress in the study of biological effects of hydrogen on higher plants and its promising application in agriculture.
  57. Review and prospect of the biomedical effects of hydrogen
  58. Detection Techniques for Hydrogen.
  59. Acarbose: a new option in the treatment of ulcerative colitis by increasing hydrogen production.
  60. A Review of Hydrogen as a New Medical Therapy.
  61. Targeting gaseous molecules to protect against cerebral ischaemic injury: mechanisms and prospects.
H2 Chemistry and Physics
  1. Is hydrogen gas in water present as bubbles or hydrated form?
  2. Chemistry and cosmology.
  3. Critical view of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (•OH/•OH–) in aqueous solution.
  4. Investigations of Quantitative Reducibility Determination and Reducibility Variations of Neutral Hydrogen-Dissolved Water by Electrochemical Analysis.
  5. Directly relating gas-phase cluster measurements to solution-phase hydrolysis, the absolute standard hydrogen electrode potential, and the absolute proton solvation energy.
  6. Astrophysical and astrochemical insights into the origin of life.
  7. Kinetic analysis of superoxide anion radical-scavenging and hydroxyl radical-scavenging activities of platinum nanoparticles.
  8. alpha-Hydroxy and alpha-amino acids under possible Hadean, volcanic origin-of-life conditions.
  9. Hydrogen the fuel for 21st century.
  10. Characteristics of hydrogen nanobubbles in solutions obtained with water electrolysis.
  11. Hydrogen particles and supersaturation in alkaline water from an Alkali-Ion-Water electrolyzer.
  12. Hydrogen concentration in water from an Alkali-Ion-Water electrolyzer having a platinum-electroplated titanium electrode.
  13. A Study of Dissolved Gas Dynamics in Mixed Stream Electrolyzed Water.
  14. Fast escape of hydrogen from gas cavities around corroding magnesium implants.
  15. An overview of industrial uses of hydrogen.
  16. Hydrated electron production by reaction of hydrogen atoms with hydroxide ions: A first-principles molecular dynamics study.
  17. Molecular studies of the structural properties of hydrogen gas in bulk water.
  18. A convenient method for determining the concentration of hydrogen in water: use of methylene blue with colloidal platinum.
  19. Behavior of Hydrogen Nanobubbles Generated in Alkaline Electrolyzed Water.
  20. Dissolution of hydrogen and the ratio of the dissolved hydrogen content to the produced hydrogen in electrolyzed water using SPE water electrolyzer.
  21. Recent progress in alkaline water electrolysis for hydrogen production and applications.
  22. Biodegradable metals.
H2 Review Articles
  1. Recently published papers: More about EGDT, experimental therapies and some inconvenient truths.
  2. The potential benefits of hydrogen-rich saline in ischemia and reperfusion injury.
  3. Future Directions in Hydrogen Studies
  4. Hydrogen therapy may be a promising, safe and effective treatment for diabetic erectile dysfunction: a hypothesis.
  5. Molecular hydrogen and radiation protection.
  6. A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution.
  7. Neuroprotective gases–fantasy or reality for clinical use?
  8. The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance.
  9. Hydrogen: another gas with therapeutic potential.
  10. Hydrogen as a novel hypothesized emerging treatment for oxidative stress in autism.
  11. Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production.
  12. Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia.
  13. The use of redox potential in water treatment processes.
  14. MOLECULAR HYDROGEN THERAPY: A MAJOR MILESTONE IN MEDICINE.
  15. Hydrogen therapy: a future option in critical care?
  16. Physico-Chemical, Biological and Therapeutic Characteristics of Electrolyzed Reduced Alkaline Water (ERAW).
  17. Hydrogen as a selective antioxidant: a review of clinical and experimental studies.
  18. Recent advances in hydrogen research as a therapeutic medical gas.
  19. Hydrogen-an endogenous antioxidant in the body.
  20. What Is Functional Water?
  21. Can hydrogen retard the progression of osteoarthritis?
  22. Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome.
  23. Hydrogen from a biologically inert gas to a unique antioxidant.
  24. Hydrogen Saline a Real Gas
  25. Therapeutic Antioxidant Medical Gas
  26. Stimulation of human damaged sperm motility with hydrogen molecule.
  27. Dietary fibre and health: the role of hydrogen production.
  28. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases
  29. [Hydrogen gas and hydrogen water act as a therapeutic and preventive antioxidant with a novel concept].
  30. Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications.
  31. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases.
  32. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
  33. The 2011 Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research
  34. Water desirable for the human body in terms of oxidation-reduction potential (ORP) to pH relationship.
  35. Molecular hydrogen: An inert gas turns clinically effective.
  36. Serum alkalinization and hydrogen-rich water in healthy men.
  37. Methods of Hydrogen Application
  38. The potential cardioprotective effects of hydrogen in irradiated mice.
  39. Hydrogen as a New Class of Radioprotective Agent.
  40. The Hypothesis of an Effective Safe and Novel Radioprotective Agent Hydrogen-rich Solution.
  41. Therapeutic Effects of Hydrogen on Different Diseases.
  42. Hydrogen: A promising novel treatment for hepatic encephalopathy?
  43. Does alkaline-reduced hexagonal water delay the aging process in Drosophila?
  44. A hypothesis on biological protection from space radiation through the use of new therapeutic gases as medical counter measures.
  45. Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight.
  46. A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine.
  47. Hydrogen gas: a novel antioxidant for chronic obstructive pulmonary disease.
  48. A hypothesis on chemical mechanism of the effect of hydrogen.
  49. Advanced research on the health benefit of reduced water.
  50. Reduced water for prevention of diseases.
  51. Hydrogen-supplemented drinking water, just soda or an elixir of life?
  52. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents.
  53. Gasotransmitters: growing pains and joys.
  54. The hydrogen highway to reperfusion therapy.
  55. Simulation study on the outlet flow dynamics of a hydride-based hydrogen storage canister for medical use.
  56. Progress in the study of biological effects of hydrogen on higher plants and its promising application in agriculture.
  57. Review and prospect of the biomedical effects of hydrogen
  58. Detection Techniques for Hydrogen.
  59. Acarbose: a new option in the treatment of ulcerative colitis by increasing hydrogen production.
  60. A Review of Hydrogen as a New Medical Therapy.
  61. Targeting gaseous molecules to protect against cerebral ischaemic injury: mechanisms and prospects.
Heart
  1. Improving outcomes from resuscitation: from hypertension and hemodilution to therapeutic hypothermia to H2.
  2. Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model.
  3. Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice.
  4. H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model.
  5. Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest, Independent of Targeted Temperature Management.
  6. Hydrogen-Rich Saline Improves Survival and Neurological Outcome after Cardiac Arrest and Cardiopulmonary Resuscitation in Rats.
  7. Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.
  8. Hydrogen-rich water attenuates experimental periodontitis in a rat model.
  9. The Effect of Hydrogen Gas on a Mouse Bilateral Common Carotid Artery Occlusion.
  10. Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration.
  11. Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-alpha/NF-kappaB pathway.
  12. Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine.
  13. Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart.
  14. Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats.
  15. Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats.
  16. Hydrogen gas protects against serum and glucose deprivation induced myocardial injury in H9c2 cells through activation of the NFE2 related factor 2/heme oxygenase 1 signaling pathway.
  17. H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs.
Human
  1. Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.
  2. Intra-Individual Ergonomics (I2E): Performance Effects of Ultra-Negative-Ion Water.
  3. Effects of drinking a water product with anti-oxidant activities in vitro on the blood levels of biomarker substances for the oxidative stress.
  4. Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis.
  5. Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients.
  6. Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water.
  7. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study.
  8. Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: A randomized, double-blind, placebo-controlled pilot study.
  9. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies.
  10. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance.
  11. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors.
  12. Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro.
  13. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.
  14. Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies
  15. Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome-An Open Label Pilot Study.
  16. Biological Effects of Electrolyzed Water in Hemodialysis.
  17. A novel bioactive haemodialysis system using dissolved dihydrogen (H-2) produced by water electrolysis: a clinical trial.
  18. A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level.
  19. Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers.
  20. Molecular Hydrogen in Sports Medicine: New Therapeutic Perspectives.
  21. Hydrogen-rich water affected blood alkalinity in physically active men.
  22. Drinks with alkaline negative oxidative reduction potential improve exercise performance in physically active men and women: Double-blind, randomized, placebo-controlled, cross-over trial of efficacy and safety.
  23. Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries.
  24. Atomic Hydrogen Surrounded by Water Molecules, H(H2O)m, Modulates Basal and UV-Induced Gene Expressions in Human Skin In Vivo.
  25. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome.
  26. Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial.
  27. Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity.
  28. Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.
  29. A Clinical Trial of Orally Administered Alkaline Reduced Water.
  30. Pilot study of H(2) therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial.
Ischemia
  1. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model.
  2. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model.
  3. The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats.
  4. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress.
  5. Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress.
  6. Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins.
  7. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury.
  8. Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits.
  9. Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle.
  10. The effect of hydrogen-rich saline on the brain of rats with transient ischemia.
  11. Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats.
  12. Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats
  13. Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats.
  14. Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits.
  15. Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines.
  16. Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model.
  17. Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway
  18. Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats.
  19. Hydrogen-Rich Saline Protects against Ischemia/Reperfusion Injury in Grafts after Pancreas Transplantations by Reducing Oxidative Stress in Rats.
  20. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.
  21. Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models.
  22. Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia.
  23. Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia. Shock, 2012. 37(6): p. 645-652.

  24. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both.
  25. A novel method of preserving cardiac grafts using a hydrogen-rich water bath.
  26. Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury.
  27. Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats.
  28. Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ischemia.
  29. Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats.
  30. Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice.
  31. Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia
  32. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion.
  33. Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap.
  34. Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.
  35. Hydrogen inhalation decreases lung graft injury in brain-dead donor rats.
  36. Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits.
  37. Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats.
Kidney
  1. Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury.
  2. Oral hydrogen water prevents chronic allograft nephropathy in rats.
  3. Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats.
  4. Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats.
  5. Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity.
  6. Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT
  7. A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats.
  8. Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging.
  9. Electrolyzed water reduces urinary protein excretion in the streptozotocin induced diabetic Dahl salt sensitive rats.
  10. Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients.
  11. Successful treatment of encapsulating peritoneal sclerosis by hemodialysis and peritoneal lavage using dialysate containing dissolved hydrogen.
  12. Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats
  13. Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water.
Liver
  1. Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation.
  2. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells.
  3. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis.
  4. Effects of Oral Intake of Hydrogen Water on Liver Fibrogenesis in Mice.
  5. Effects of oral intake of hydrogen water on liver fibrogenesis in mice.
  6. Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats.
  7. Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells.
  8. Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice.
  9. Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release.
  10. Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass.
  11. Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats.
  12. Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats.
  13. Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning.
  14. The protective role of hydrogen-rich saline in experimental liver injury in mice.
  15. Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats.
  16. Dialysate with high dissolved hydrogen facilitates dissociation of indoxyl sulfate from albumin.
  17. Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice.
  18. Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning.
  19. Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine.
  20. Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats
  21. Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-?B signaling pathway
  22. Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.
Lung and other organs
  1. Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock.
  2. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model.
  3. The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac deathdagger.
  4. Hydrogen inhalation ameliorates ventilator-induced lung injury.
  5. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation.
  6. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.
  7. Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice.
  8. Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury
  9. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats.
  10. Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats.
  11. Hydrogen Therapy may be a Novel and Effective Treatment for COPD.
  12. Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury.
  13. Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury.
  14. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats.
  15. Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats.
  16. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice.
  17. Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation
  18. Effects of hydrogen water on paraquat-induced pulmonary fibrosis in mice.
  19. Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats.
  20. Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury.
  21. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement.
  22. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress.
  23. Effects of hydrogen-rich water on aging periodontal tissues in rats
  24. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma.
  25. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis
  26. Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats.
  27. Effect of hydrogen-rich water on acute peritonitis of rat models.
  28. Saturated hydrogen saline protects the lung against oxygen toxicity.
Metabolic Syndrome
  1. Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level, in Animal Cell Technology: Basic & Applied Aspects.
  2. Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle.
  3. Antibacterial Activity of Hydrogen-rich Water Against Oral Bacteria.
  4. Effect of alkaline reduced water on erythrocyte oxidative status and plasma lipids of spontaneously hypertensive rats.
  5. Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model.
  6. Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways.
  7. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial.
  8. Effect of mineral induced alkaline reduced water on sprague-dawley rats fed on a high fat diet.
  9. Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model.
  10. Protective Effects of Hydrogen-Rich Saline Against Erectile Dysfunction in a Streptozotocin Induced Diabetic Rat Model.
  11. Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model.
  12. The suppressive effect of electrolyzed reduced water on lipid peroxidation.
  13. Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model.
  14. Protection of oral hydrogen water as an antioxidant on pulmonary hypertension.
  15. Anti-obesity effect of alkaline reduced water in high fat-fed obese mice.
  16. Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells.
  17. Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis.
  18. Anti-diabetic effect of alkaline-reduced water on OLETF rats.
  19. Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice.
  20. Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice
  21. Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice.
  22. Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice.
  23. Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species.
  24. Effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic b HIT-T15 cell.
  25. Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus.
  26. Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water.
  27. Electrolyzed and natural reduced water exhibit insulin-like activity on glucose uptake into muscle cells and adipocytes.
  28. Consumption of hydrogen water prevents atherosclerosis in apoliporotein E knockout mice.
  29. Anti-oxidative water improves diabetes
  30. Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles.
  31. H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells.
  32. Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice.
  33. Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats.
  34. Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model.
  35. Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress.
  36. Protective effects of hydrogen-rich saline in preeclampsia rat model.
  37. Anti Type 2 Diabetic Effect and Anti-oxidation Effect in Active Hydrogen Water Administration KK-Ay Mice.
  38. Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage.
  39. Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats.
  40. Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats.
  41. Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters.
  42. Effects of alkaline ionized water on spontaneously diabetic GK-rats fed sucrose.
Pain
  1. H Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain.
  2. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress.
  3. Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats.
  4. Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells.
  5. Molecular hydrogen attenuates neuropathic pain in mice.
  6. Fundamental properties of electrolyzed water.
  7. Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats.
  8. Biological toxicity of acid electrolyzed functional water: effect of oral administration on mouse digestive tract and changes in body weight.
  9. Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function.
  10. Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses.
  11. Regulative effects of hydrogen-rich medium on monocytic adhesion and vascular endothelial permeability
  12. Effect of electrolyzed water on wound healing.
  13. Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo.
Safety
  1. Evaluate of Electrochemical Characteristics in Electrolyzed Reduced Water.
  2. Metabolism and thermoregulation in guinea pigs in hyperbaric hydrogen: Effects of pressure.
  3. The immunological effects of electrolyzed reduced water on the Echinostoma hortense infection in C57BL/6 mice.
  4. Systemic and local effects of long-term exposure to alkaline drinking water in rats.
  5. Protective effect of hydrogen-rich saline on decompression sickness in rats.
  6. Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity.
  7. Influence of alkaline ionized water on rat erythrocyte hexokinase activity and myocardium.
  8. Degradation of myocardiac myosin and creatine kinase in rats given alkaline ionized water.
  9. Influences of alkaline ionized water on milk yield, body weight of offspring and perinatal dam in rats.
  10. Histopathological influence of alkaline ionized water on myocardial muscle of mother rats.
  11. Influences of alkaline ionized water on milk electrolyte concentrations in maternal rats.
  12. The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice.
  13. Hepatotoxicity of sub-nanosized platinum particles in mice.
  14. Acute and chronic nephrotoxicity of platinum nanoparticles in mice.
    Sepsis, Gastritis, Intestine
    1. Effect of glutamine or alkaline ionized water on late diarrhea induced by irinotecan hydrochloride in Gunn rats.
    2. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury
    3. Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation.
    4. Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages.
    5. Protective effects of hydrogen-rich saline on ulcerative colitis rat model.
    6. The Effect of Mineral-induced Alkaline Reduced Water on the DSS-induced Acute inflammatory Bowel Disease Mouse Model.
    7. Hydrogen May Be Used as a Treatment for Stress-Induced Gastric Ulceration.
    8. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.
    9. Effects of hydrogen-rich saline treatment on polymicrobial sepsis.
    10. The protective of hydrogen on stress-induced gastric ulceration.
    11. Potential ghrelin-mediated benefits and risks of hydrogen water
    12. Chronic administration with electrolyzed alkaline water inhibits aspirin-induced gastric mucosal injury in rats through the inhibition of tumor necrosis factor-alpha expression.
    13. Colonic hydrogen generated from fructan diffuses into the abdominal cavity and reduces adipose mRNA abundance of cytokines in rats.
    14. Senn on the Diagnosis of Gastro-Intestinal Perforation by the Rectal Insufflation of Hydrogen Gas.
    15. Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats.
    16. Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats.
    17. Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water.
    18. [Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice].
    19. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.
    20. Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis.
    21. Hydrogen gas presents a promising therapeutic strategy for sepsis.
    22. Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water.
    23. Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats.
      Skin and Radiation
      1. Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals.
      2. Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice.
      3. Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats.
      4. The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice.
      5. The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice.
      6. Protection by hydrogen against gamma ray-induced testicular damage in rats.
      7. Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes.
      8. Effect of several electrolyzed waters on the skin permeation of lidocaine, benzoic Acid, and isosorbide mononitrate.
      9. Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway
      10. Eumelanin-driven production of molecular hydrogen: A novel element of skin defense?
      11. Radioprotective effect of hydrogen in cultured cells and mice.
      12. Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage
      13. Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation.
      14. Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig.
      15. Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis.
      16. Molecular hydrogen protects human lymphocyte AHH-1 cells against C heavy ion radiation.
      17. Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice.
      18. Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice.
      19. Hydrogen-enriched water restoration of impaired calcium propagation by arsenic in primary keratinocytes
      20. Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice.
      21. Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction.
        Spine and Pancreas
        1. Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats.
        2. Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats.
        3. Research advances on hydrogen therapy in nervous system diseases.
        4. Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats.
        5. Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice.
        6. Experimental studies of effects of hydrogen-rich saline in rats with severe acute pancreatitis
        7. Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat.

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